PREGABALINS IN THE MANAGEMENT OF DIABETIC AND ALCOHOLIC POLYNEUROPATHY

Diseases of the peripheral nervous system are ranking a leading position among other neurological nosologies. And polyneuropathy is known as more prevalent and severe disease. Numerous scientific reports highlight issues on different pathological conditions in relation to polyneuropathy, particular intoxications, hypovitaminosis (isolated or complications certain processes), infectious hereditary diseases, paraneoplastic syndromes, metabolic disorders, allergic reactions. These diseases when uncontrolled untreated may result development complications, which polyneuropathy. The diagnosis relatively not difficult, because disease manifested distal symmetrical sensory and/or motor impairments with transient disorders autonomic system. Diabetic particular, late complication diabetes mellitus, determines prognosis Alcoholic form acute, subacute chronic current variants caused by combined effects thiamine toxicity vitamin deficiency. At same time, dysmetabolic polyneuropathies differ variability clinical manifestations general developmental patterns nerve conduction block that determined peculiarities degenerative regenerative processes under pathogenetic factors. Differential mainly based detection somatic pathology comparison dynamic changes course manifestations. study has demonstrated diabetic alcoholic have clear distinct clinical-neurophysiological patterns. article also highlights treatment outcomes combination therapy pregabalin for polyneuropathies.